학력사항

• Ph.D. 경희대학교 의과대학 생리학교실

경력사항

• 2005–현재 경희대학교 간호과학대학 교수
• 2013. 9-2015. 8 경희대학교 간호과학대학 부학장 / 대학원 학과장
• 2010-2012 경희대학교 동서간호학연구소장
• 2007. 9-2009. 9 경희대학교 간호과학대학 간호학과장
• 2024-현재 한국기초간호학회 감사
• 2022-2023 한국기초간호학회 회장
• 2020-2021 한국기초간호학회 부회장
• 2008-2019 한국기초간호학회 학술 / 교육연구이사
• 2024-현재 한국간호과학회 감사
• 2008-2019 한국간호과학회 학술위원/교육위원/코호트 특별위원
• 2010-2012 한국여성과학기술단체 총연합회 학술대회 조직위원
• 2023-현재 경희대학교병원 겸직교수
• 2009-2011 경희의료원 국제학술지 진흥위원회 위원
• 2009-현재 한국기초간호학회지(JKBNS) 논문심사위원
• 2009-현재 Asian Nursing Research(ANR) 논문심사위원
• 2009-현재 한국간호과학회(JKAN) 논문심사위원 / 편집위원
• 2009-현재 한국운동재활학회지 편집위원회 이사
• 2018-현재 부산대학교 간호과학연구소 ‘글로벌 건강과 간호’ 심사위원
• 2017-현재 ㈜넥스모스 고문

연구관심분야

• 노화
• 신경과학
• 퇴행성뇌질환
• 후성유전학
   
   

강의분야

• 생리학
• 병태생리학
• 약리학
• 신경과학
• 유전체학과 간호

연구실적

• NXP032 ameliorates cognitive impairment by alleviating the neurovascular aging process in aged mouse brain. SCIENTIFIC REPORTS 13(1) 2023
• Efficacy of Artemisia annua Linné in improving cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia animal model. Phytomedicine 112 2023
• Blockade on Lin28a Prevents Cognitive Impairment and Disruption of the Blood-Brain Barrier Induced by Chronic Cerebral Hypoperfusion. BIOMEDICINES 10(4) 2022 
• NXP032 Ameliorates Aging-Induced Oxidative Stress and Cognitive Impairment in Mice through Activation of Nrf2 Signaling. Antioxidants 11(1) 2022
• Antidepressant effects of capsaicin in rats with chronic unpredictable mild stress-induced depression. Journal of Korean Biological Nursing Science 25(1) 2023
• Morus Nigra Extract Attenuates Cognition Impairment and GABAergic Interneuron Degeneration in Aged Rat Brain. Journal of Korean Biological Nursing Science 24(2) 2022
• Muscle Radiation Attenuation in the Erector Spinae and Multifidus Muscles as a Determinant of Survival in Patients with Gastric Cancer. Journal of Korean Biological Nursing Science 24(1) 2022
• Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging. Experimental Gerontology155(1), 2021
• Muscle-related parameters as determinants of survival in patients with stage I-III gastric cancer undergoing gastrectomy. Journal of cancer 12(18), 2021
• Nxp031 improves cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia rat model through nrf2 signaling. International Journal of Molecular Sciences 22(12), 2021
• Effect of chronic handling and social isolation on emotion and cognition in adolescent rats. Physiology and Behavior 237, 2021
• Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway. Biological Research for Nursing 23(2), 2021
• Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model. NEUROSCIENCE LETTERS 740, 2021
• Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion. International Neurourology Journal 25(1)
• Low-intensity treadmill exercise protects cognitive impairment by enhancing cerebellar mitochondrial calcium retention capacity in a rat model of chronic cerebral hypoperfusion. Journal of exercise rehabilitation 17(5), 2021
• Neuroprotective effect of NXP031 in the MPTP-induced Parkinson’s disease model.(2021) Neuroscience Letters 740:135425
• Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway. (2021) Biological Research for Nursing. in print.
• Accelerated Epigenetic Age in Normal Cognitive Aging of Korean Community-Dwelling Older Adults(2021) Geriatrics & Gerontology International. in print.
• Effects of long-term and short-term consumption of energy drinks on cognitive behavior in adolescent rats. (2020) Journal of Korean Biological Nursing Science 22(2):111-118
• Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model.(2020) Brain Research Bulletin 163-1:160-169
• The alleviation effects of sweet drinks on restraint stress induced anxiety and depressive behavior in adolescent rats.(2020) Journal of Korean Biological Nursing Science 22(4):111-118
• Effect of Ghrelin on memory impairment in a rat model of vascular dimentia. J Korean Acad Nurs. (2019) 49-3:317-329
• Effect of treadmill exercise on spatial navigation impairment associated with cerebellar Purkinje cell loss following chronic cerebral hypoperfusion. (2018) Molecular medicin report 17:8121-8128
• Genome-wide DNA methylation profiling in a rat model with vascular dementia. (2018) Molecular medicine report 18:123-130
• Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats. Journal of Korean Biological Nursing Science (2017) 19(4);276-283
• The Effect of Long-Term Environmental Enrichment in Chronic Cerebral Hypoperfusion-Induced Memory Impairment in Rats. Biological Research for Nursing (2017) 19(3);278-286
• The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats. Neuroscience letter (2017) 638;83-89
• Comparison of the behavioral effects of exercise and high fat diet on cognitive function in adolescent rats. Journal of Exercise Rehabilitation (2016) 12(6);520-525
• Alteration of Energy Metabolism and Antioxidative Processing in the Hippocampus of Rats Reared in Long-Term Environmental Enrichment. Dev Neurosci (2016) 38(3);186-184
• Neurorestorative effect of erythropoietin and environmental enrichment in the early stage of stroke recovery. Animal Cells and Systems. (2016) 20(3);165-173
• Protective effect of ginsenoside Re on acute gastric mucosal lesion induced by compound 48/80. J Ginseng Res (2014) 38;89-96
• Decreased Pattern-Recognition Receptor-Mediated Cytokine mRNA Expression in Obese Children With Otitis Media With Effusion. Clinical and Experimental Otorhinolaryngology (2014) 7(1);7-12
• Effect of HDAC Inhibitors on Neuroprotection and Neurite Outgrowth in Primary Rat Cortical Neurons Following Ischemic Insult. Neurochem Res (2013) 38;1921-1934
• Poststroke depression and emotional incontinence: factors related to acute and subacute stages. Neurology. 2012 Apr 10;78(15):1130-7
• Role of Matrix Metalloproteinase 3-mediated a-synuclein cleasvage in dopaminergic cell death. The Journal of Biological Chem. (2011) 286-16; 14168-14177
• Acupuncture attenuates neuronal cell death in middle cerebral artery occlusion model of focal ischemia. Neurol Research. 32(1); 84-87, 2010
• Mechanisms and Prospects of Ischemic Tolerance induced by Cerebral Preconditioning. International Neurourology Journal(2010) 14-4; 200-208

• ‘알츠하이머 치매 동물 모델에서 복합적 환경 중재에 따른 뇌혈관 조절 기전 연구’, 중견후속연구 (2023-2026), 한국연구재단
• ‘알츠하이머 치매 동물 모델에서 압타민C를 이용한 후보물질 최적화 연구’, 기업과제 (2022-2024), ㈜ 넥스모스
• ‘알츠하이머 치매 동물 모델에서 압타민 C의 치료적 접근’, 기업과제 (2021-2023), ㈜ 넥스모스